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Carcinogenesis In the life span carcinogenicity analyze performed in B6C3F1 mice, methylphenidate caused an increase in hepatocellular adenomas, As well as in males only, a rise in hepatoblastomas at a daily dose of approximately 60 mg/kg/day. This dose is around two occasions the MRHD of 60 mg/day given to small children on mg/m2 basis.Really Spec